This handbook provides guidance for national TB control programmes and organizations responsible for delivering TB control in developing and implementing an mTB-Tobacco programme. The main components of which are: operations management, content development and adaptation, promotion and recruitment, technology specifications and monitoring and evaluation. The content of the mTB-Tobacco programme will complement existing health care services and routine care offered by health care professionals. All content in this handbook is based on WHO guidelines, existing research evidence on effectiveness, content and delivery and expert opinions. The templates showcased here should be considered examples and must be adapted to local context of each participating country.